Fatty Acid Chain Shortening by a Fungal Peroxygenase

  • A recently discovered peroxygenase from the fungus Marasmius rotula (MroUPO) is able to catalyze the progressive one-carbon shortening of medium and longchain mono- and dicarboxylic acids by itself alone, in the presence of H₂O₂. The mechanism, analyzed using H₂O, starts with an a-oxidation catalyzed by MroUPO generat- ing an α-hydroxy acid, which is further oxidized by the enzyme to a reactive α-keto intermediate whose decarboxylation yields the one-carbon shorter fatty acid. Compared with the previously characterized peroxygenase of Agrocybe aegerita, a wider heme access channel, enabling fatty acid positioning with the carboxylic end near the heme cofactor (as seen in one of the crystal structures available) could be at the origin of the unique ability of MroUPO shortening carboxylic acid chains.

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Metadaten
Author: Andrés Olmedo, José C. del Río, Jan Kiebist, René UllrichORCiD, Martin HofrichterORCiD, Katrin Scheibner, Angel T. Martínez, Ana Gutiérrez
DOI:https://doi.org/10.1002/chem.201704773
ISSN:1521-3765
ISSN:0947-6539
Title of the source (English):Chemistry A European Journal
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2017
Tag:Peroxygenase
Volume/Year:23
Number of pages:16985
First Page:16989
Last Page:67
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Enzymtechnologie
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