Growth induction and low-oxygen apoptosis inhibition of human CD34+ progenitors in collagen gels

  • Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34(+) cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.

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Metadaten
Author: Daniele Avitabile, Katrin Salchert, Carsten Werner, Maurizio C. Capogrossi, Maurizio Pesce
DOI:https://doi.org/10.1155/2013/542810
ISSN:2314-6133
ISSN:2314-6141
Title of the source (English):BioMed Research International
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2013
First Page:542810
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Naturstoffchemie
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